Bpsbioscience/Human Interleukin-2/90184-B/50 µg
商品编号：
90184-B
品牌：
bpsbioscience
市场价：
¥4100.00
美元价：
2460.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species: Human
Host Species: E. coli
MW: 15 kDa
Genbank #: P60568
a.a: 21–153
Background:
IL-2 is produced mainly by T- cells expressing the surface antigen CD4 following cell activation by mitogens or allogen. Interleukin-2 (IL-2) has multiple, sometimes opposing, functions during an inflammatory response. It is a potent inducer of T-cell proliferation and T- helper 1 (Th1) and Th2 effector T-cell differentiation and provides T cells with a long-lasting competitive advantage resulting in the optimal survival and function of memory cells. In a regulatory role, IL-2 is important for the development, survival, and function of regulatory T cells, it enhances Fas-mediated activation-induced cell death, and it inhibits the development of inflammatory Th17 cells. Thus, in its dual and contrasting functions, IL-2 contributes to both the induction and the termination of inflammatory immune responses.
Description:
Recombinant Interleukin-2 is a disulfide-linked monomer protein consisting of 133 amino acid residues, migrates as an approximately 15 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding human Interleukin-2 mature chain was expressed in E. coli.
UniProt
P60568
Synonym(s):
IL-2, Lymphokine, TCGF, T Cell Growth Factor, Aldesleukin, Interleukin-2, IL2
Purity:
≥97% by SDS-PAGE and HPLC
Endotoxin Level:
<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.
Biological Activity:
The ED50 was determined by the dose dependent proliferation of murine CTLL-2 cells and was found to be less than 0.1 ng/ml , corresponding to a specific activity of >2.0x 107units/mg.
Formulation:
Lyophilized from 0.2 µm filtered concentrated (1 mg/ml) solution in PBS, pH 7.2.
Format:
lyophilized protein
Reconstitution:
Reconstitute at 0.1-1.0 mg/ml in distilled water. This solution can then be diluted into other buffers. To maximize product collection from vial surface, vortex briefly and then spin down to recollect the liquid.
Storage / Stability:
The lyophilized protein is stable for at least 2 years from date of receipt when stored at -20°C. Upon reconstitution, store in working aliquots at +4°C for up to one month, or at -20°C for up to six months, in the presence of a carrier protein. Avoid repeated freeze/thaw cycles.
Reference(s):
1. Shevach EM. Trends Immunol. 2012 Dec,33(12):626-32.
2. Dooms H, Abbas AK. Eur J Immunol. 2010 Jun,40(6):1538-40.
2. Dooms H, Abbas AK. Eur J Immunol. 2010 Jun,40(6):1538-40.
Warning(s):
Avoid freeze/thaw cycles
Amino Acid Sequence:
APTSSSTKKT QLQLEHLLLD LQMILNGINN YKNPKLTRMLTFKFYMPKKA TELKHLQCLE EELKPLEEVL NLAQSKNFHL RPRDLISNIN VIVLELKGSETTFMCEYADE TATIVEFLNR WITFAQSIIS TLT
Scientific Category:
Cytokine/Growth Factors
Product Type:
Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
