Bpsbioscience/Human Interleukin-15/90180-A/2 µg
商品编号：
90180-A
品牌：
bpsbioscience
市场价：
¥1640.00
美元价：
984.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species:Human
HostSpecies:E.coli
MW:13kDa
Genbank#:P40933
a.a:49–162
Background:
IL-15hasbeenshowntobeproducedbyhumanfetalastrocytesandmicroglialcellsinresponsetoIL-1beta,IFN-gamma,orTNF-alphaandmaythusplayaroleinT-cellmediatedimmuneresponsesinthehumancentralnervoussystem.IL-15stimulatesproliferationoftheestablishedT-celllineCTLL-2,CD8(+)memoryT-cellsrequireIL-15forproliferation.IL-15isalsoabletoinducegenerationofcytolyticcellsandLAKcellsactivityinvitro.IL-15appearstofunctionasaspecificmaturationfactorforNK-cellsandcanmimicthebonemarrowmicroenvironmentinvitro,whichisrequiredforNK-cellstoacquirelyticfunctions.IL-15inducesproliferationofmastcellsintheabsenceoffunctionalIL-2receptorcomponentsandutilizesareceptorof60-65kDathatisdistinctfromknowncomponentsofT-cellIL-15receptors.TheIL-15receptoronmastcellsrecruitsJAK2andSTAT5,insteadofJAK1,JAK3,andSTAT3andSTAT5thatareactivatedinT-cells.ThealphasubunitoftheIL-15receptor(IL-15RA)isstructurallyrelatedtothealphasubunitoftheIL-2receptorandconfershighaffinitybindingofIL-15toitsreceptor.IL-15bindstothebetaandgammachainsoftheIL2receptor,whichareknowntoberequiredforligandinternalizationandsignaltransduction.
Description:
RecombinantInterleukin-15isadisulfide-linkedhomodimericproteinconsistingoftwo115aminoacidresidues,andmigratesasanapproximately13kDaproteinundernon-reducingconditionsandreducingconditionsinSDS-PAGE.OptimizedDNAsequenceencodinghumanInterleukin-15maturechainwasexpressedinE.coli.
UniProt
P40933
Synonym(s):
IL-15,IL15,Interleukin-15
Purity:
≥96%bySDS-PAGEandHPLC
EndotoxinLevel:
<0.1ng/µg(1EU/µg),usingtheLALgelclotmethod.
BIOLOGicalActivity:
TheED50wasdeterminedbythedose-dependentproliferationofmouseCTLL-2cellsandwasfoundlessthan0.3ng/ml.
Formulation:
Lyophilizedfrom0.2µmfilteredPBS,pH7.5.
Format:
lyophilizedprotein
Reconstitution:
Reconstituteat0.1-1.0mg/mlindistilledwater.Thissolutioncanthenbedilutedintootherbuffers.Tomaximizeproductcollectionfromvialsurface,vortexbrieflyandthenspindowntorecollecttheliquid.
Storage/StABIlity:
Thelyophilizedproteinisstableforatleast2yearsfromdateofreceiptwhenstoredat-20°C.Uponreconstitution,storeinworkingaliquotsat+4°Cforuptoonemonth,orat-20°Cforuptosixmonths,inthepresenceofacarrierprotein.Avoidrepeatedfreeze/thawcycles.
Reference(s):
1.J.Immunol.,Sep2009,183:3574-3577.
2.PNAS,Sep2009,106:15849-15854.
3.Mol.CancerTher.,Sep2009,8:2736-2745.
2.PNAS,Sep2009,106:15849-15854.
3.Mol.CancerTher.,Sep2009,8:2736-2745.
Warning(s):
Avoidfreeze/thawcycles
AminoAcidSequence:
NWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS
ScientificCategory:
Cytokine/GrowthFactors
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
