Bpsbioscience/Human Interferon-gamma/90162-B/100 µg
商品编号：
90162-B
品牌：
bpsbioscience
市场价：
¥4100.00
美元价：
2460.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species:Human
HostSpecies:E.coli
MW:17kDa
Genbank#:P01579
a.a:24–166
Background:
IFN-gammaisproducedmainlybyT-cellsandnaturalkillercellsactivatedbyantigens,mitogens,oralloantigens.ItisproducedbylymphocytesexpressingthesurfaceantigensCD4andCD8.IFNgammareceptorsareexpressedonalltypesofhumancellswiththeexceptionofmatureerythrocytes.IFN-gamma-receptorcomplexesarerapidlyinternalizedbyendocytosis.IFN-gammahasantiviralandantiparasiticactivitiesandalsoinhibitstheproliferationofanumberofnormalandtransformedcells.Interferon-gammasynergiseswithTNF-alphaandTNF-betaininhibitingtheproliferationofvariouscelltypes.ThegrowthinhibitoryactivitiesofIFN-gammaaremorepronouncedthanthoseoftheotherinterferons.However,themainBIOLOGicalactivityofIFN-gammaappearstobeimmunomodulatoryincontrasttotheotherinterferonsthataremainlyantiviral.InT-helpercells,IL-2inducesthesynthesisofIFN-gammaandothercytokines.IFN-gammaactssynergisticallywithIL-1andIL-2andappearstoberequiredfortheexpressionofIL-2receptorsonthecellsurfaceofT-lymphocytes.BlockingoftheIL-2receptorbyspecificantibodiesalsoinhibitsthesynthesisofIFN-gamma.
Description:
RecombinantInterferongammaisadisulfide-linkedmonomerproteinconsistingof144aminoacidresidues,andmigratesasanapproximately17kDaproteinundernon-reducingandreducingconditionsinSDS-PAGE.OptimizedDNAsequenceencodingHumanInterferon-gammamaturechainwasexpressedinE.coli.
UniProt
P01579
Synonym(s):
IFNG,Interferongamma,IFG
Purity:
≥98%bySDS-PAGEandHPLC
EndotoxinLevel:
<0.1ng/µg(1EU/µg),usingtheLALgelclotmethod.
Formulation:
Lyophilizedfrom0.2µmfilteredconcentrated(1mg/ml)solutioninPBS,pH7.2.
Format:
lyophilizedprotein
Reconstitution:
Reconstituteat0.1-1.0mg/mlindistilledwater.Thissolutioncanthenbedilutedintootherbuffers.Tomaximizeproductcollectionfromvialsurface,vortexbrieflyandthenspindowntorecollecttheliquid.
Storage/StABIlity:
Thelyophilizedproteinisstableforatleast2yearsfromdateofreceiptwhenstoredat-20°C.Uponreconstitution,storeinworkingaliquotsat+4°Cforuptoonemonth,orat-20°Cforuptosixmonths,inthepresenceofacarrierprotein.Avoidrepeatedfreeze/thawcycles.
Reference(s):
1.SikorskiK,etal.CytokineGrowthFactorRev.2011Aug,22(4):211-9.
2.GysemansC,etal.BiochemSocTrans.2008Jun,36(Pt3):328-33.
3.RameshwarP.CellRes.2008Aug,18(8):805-6.
2.GysemansC,etal.BiochemSocTrans.2008Jun,36(Pt3):328-33.
3.RameshwarP.CellRes.2008Aug,18(8):805-6.
Warning(s):
Avoidfreeze/thawcycles
AminoAcidSequence:
QDPYVKEAENLKKYFNAGHSDVADNGTLFLGILKNWKEESDRKIMQSQIVSFYFKLFKNFKDDQSIQKSVETIKEDMNVKFFNSNKKKRDDFEKLTNYSVTDLNVQRKAIHELIQVMAELSPAAKTGKRKRSQMLFRGRRASQ
ScientificCategory:
Cytokine/GrowthFactors
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
