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当前位置: 首页 > 产品中心 > Routine_cell_strain > Bpsbioscience/NaV1.7–HEK293重组细胞系/60507/2小瓶
商品详细Bpsbioscience/NaV1.7–HEK293重组细胞系/60507/2小瓶
Bpsbioscience/NaV1.7–HEK293重组细胞系/60507/2小瓶
Bpsbioscience/NaV1.7–HEK293重组细胞系/60507/2小瓶
商品编号: 60507
品牌: bpsbioscience
市场价: ¥176000.00
美元价: 105600.00
产地: 美国(厂家直采)
公司:
产品分类: 常规细胞株
公司分类: Routine_cell_strain
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Species:Human
MW:242kDa(calc.)
Genbank#:Q15858
Background:
Nav1.7isavoltage-gatedsodiumionchannelthatinhumansisencodedbytheSCN9Agene.Itisusuallyexpressedathighlevelsintwotypesofneurons,thenociceptiveneuronsatdorsalrootganglionandtrigeminalganglion,andsympatheticganglionneurons,whicharepartoftheautonomic(involuntary)nervoussystem.Nav1.7ispresentattheendingsofpain-sensingnerves,thenociceptors,closetotheregionwheretheimpulseisinitiated.TheNav1.7channelproducesarapidlyactivatingandinactivatingcurrentwhichissensitivetotheleveloftetrodotoxin.KnockoutmicethatlackNav1.7innociceptorsshowedreducedresponsetoinflammatorypain.
Description:
StablerecombinantHEK293celllineexpressinghumanNav1.7(Genbank#Q15858)fusedattheC-terminustoGreenFluorescentProtein[Ex.~395nm,475nm;em~510nm]andwithCterminalStreptavidin-BindingPeptide(SBP)fusion.Nav1.7isatetrodotoxin-sensitivevoltagegatedsodiumchanneltypeIXsubunitalpha(SCN9A).
UniProt
Q15858
Synonym(s):
Nav1.7,SCN9A,tetrodotoxin-sensitivevoltage-gatedsodiumchanneltypeIXsubunitalpha
SuppliedAs:
Eachvialcontains~2X106cellsin1mlof10%DMSO.
BIOLOGicalActivity:
FunctionallyvalidatedbyWesternblottingofNaV1.7usinganti-SodiumchannelNav1.7,cloneN68/6(Millipore,#MABN41)andAlkalinePhosphataseconjugatedanti-mouseIgG.AlsovalidatedforNaV1.7expressionbyintracellularflowcytometry(FACS)usinganti-NaV1.7clone68/6andPE-labeledanti-mouseIgG.
HostCellline:
HEK293cells
Instructionsforuse:
Seecelllinedatasheetfordetailedculturingandassayprotocol.
Storage/StABIlity:
Storeinliquidnitrogenimmediatelyuponreceipt.
Application(s):
•ScreenforactivatorsorinhibitorsofNav1.7
•FunctionalassaysforNav1.7
•Efficientantigenformouseimmunization
Reference(s):
1.Catterall,W.A.CellandDevelopmentalBiology16:521–555(2000).
2.Choi,J.S.,etal.Neurology67:1563-1567(2006).
3.Li,Y.,elal.ProteinScience20(1):140–149(2011).
Notes:

Contactusforpricing.

LicenseDisclosure:Purchaseofthiscelllinegrantsyouwitha10-yearlicensetousethiscelllineinyourimmediatelaboratory,forresearchuseonly.Thislicensedoesnotpermityoutoshare,distribute,sell,sublicense,orotherwisemakethecelllineavailableforusetootherlaboratories,departments,researchinstitutions,hospitals,universities,orbiotechcompanies.Thelicensedoesnotpermituseofthiscelllineinhumansorfortherapeuticordruguse.Thelicensedoesnotpermitmodificationofthecelllineinanyway.InappropriateuseordistributionofthiscelllinewillresultinrevocationofthelicenseandresultinanimmediateceaseofsalesanddistributionofBPSproductstoyourlaboratory.BPSdoesnotwarrantthesuitabilityofthecelllineforanyparticularuse,anddoesnotacceptanyliabilityinconnectionwiththehandlingoruseofthecellline.Modificationsofthiscellline,transfertoanotherfacility,orcommercialuseofthecellsmayrequireaseparatelicenseandadditionalfees;contactsales@bpSBIoscience.comfordetails.PublicationsusingthiscelllineshouldreferenceBPSBioscience,Inc.,SanDiego.

Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
ionchannel
ProductType:
CellLine
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介:为生命科学研究提供ELISA试剂盒(仅供科研)、抗体和抗原(仅供科研)、流式抗体,使您的检测结果更稳定可靠,用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀,吸附性好,空白值低,孔底透明度高,代做ELISA实验等。