Bpsbioscience/I-CBP112 (Hydrochloride)/27336/1 mg
商品编号：
27336
品牌：
bpsbioscience
市场价：
¥900.00
美元价：
540.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:505.1Da
CASRegistry#:NA
Formula:C27H36N2O5
Target:CREBBP,EP3000
Description:
I-CBP112(Hydrochloride)isaselectiveinhibitorofcAMPresponsive-elementbindingprotein(CREBBP)andE1Abindingproteinp3000(EP3000).TheinhibitorhasbeenshowntodecreaseEZH2activityandtoinhibittrimethylationoflysine27onhistoneH3inculturedhumanAMLHL-60andOCI-AML3cells.IthasthesameeffectonprimaryAMLcellsinadose-dependentmanner.
Synonym(s):
ICBP112,ICBP
SuppliedAs:
Acrystallinesolid
BIOLOGicalActivity:
I-CBP112directlybindsthebromodomainsofCREBBPandEP300withaKDof0.5and0.625μM,respectively.Itshowsweakcross-reactivitywithbromodomainandextra-terminal(BET)proteinsandnoreactivitywithotherbromodomain-containingproteins.
Solubility:
SolubleinDMSO,ethanol,anddimethylformamideatapproximately16mg/ml.
Storage/StABIlity:
Storeatorbelow-20°Cforuptotwoyears.Protectstocksolutionsfrommoisture.Avoidfreeze/thawcycles.
Reference(s):
1.Iver,N.G.etal.,Oncogene.2004;23(24):4225-4231.
2.Petrij,F.etal.,Nature.1995;376(6538):348-351
3.Vizmanos,J.L.etal.,GeneChromsomeCanc.2003;36:402-405
Warning(s):
Avoidfreeze/thawcycles.
ScientificCategory:
Bromodomain
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
