Bpsbioscience/I-BET151 (GSK1210151A)/27629-2/10 mg
商品编号：
27629-2
品牌：
bpsbioscience
市场价：
¥4300.00
美元价：
2580.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:415.4Da
CASRegistry#:1300031-49-5
Formula:C23H21N5O3
Target:BET
Background:
Bromodomainshaveanimportantroleinthetargetingofchromatin-modifyingenzymestospecificsites,includingmethyltransferases,HATsandtranscriptionfactorsandregulatediverseBIOLOGicalprocessesfromcellproliferationanddifferentiationtoenergyhomeostasisandneurologicalprocesses.OptimizedtoretainexcellentBETtargetpotencyandselectivitywhileenhancingtheinvivopharmacokineticsandterminalhalf-lifetoenableprolongedinvivostudies.
Description:
I-BET151(GSK1210151A)isaBETbromodomaininhibitor.I-BET151displayspotentbindingaffinitytoBRD2,BRD3andBRD4withKdof0.02-0.1µM.I-BET151(0.5or5µM)inhibitsthebindingofBETs(BRD2,BRD3,BRD4,andBRD9)butnotthebindingof23otherbromodomainproteins.I-BET151alsoblocksrecruitmentofBETtochromatin.
Synonym(s):
I-BET151;GSK1210151A;7-(3,5-dimethyl-1,2-oxazol-4-yl)-8-methoxy-1-[(1R)-1-pyridin-2-ylethyl]-3H-imidazo[4,5-c]quinolin-2-one
BiologicalActivity:
I-BET151(GSK1210151A)isanovelselectiveBETinhibitorforBRD2,BRD3andBRD4withIC50of0.5µM,0.25µM,and0.79µM,respectively.
Solubility:
SolubleinDMSO83mg/ml(199mM),water<1mg/ml(<1mM),ethanol27mg/ml(64mM)
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
Dawsonetal.(2011).Nature478:529.
ScientificCategory:
BromodomainInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
