Bpsbioscience/Z-VDVAD-FMK/27668-1/5毫克
商品编号：
27668-1
品牌：
bpsbioscience
市场价：
¥7600.00
美元价：
4560.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW: 695.7 Da
CAS Registry #: 210344-95-9
Formula: C32H46N5O11F
Target: Caspase 2
Background:
VDVAD has been shown to be a preferred cleavage site for caspase-2. Caspase 2 is a very versatile caspase with multiple functions. It is a member of the family of cysteine proteases called caspases that cleave proteins only at an amino acid following an aspartic acid residue. Within this family, caspase 2 is part of the Ich-1 subfamily. Caspase 2 has a similar amino acid sequence to initiator caspases, including caspase 1, caspase 4, caspase 5, and caspase 9. It is produced as a zymogen with a long pro-domain. Pro-caspase-2 contains two subunits, p19 and p12. Caspase 2 associates with several proteins involved in apoptosis via its CARD domain, including RAIDD, ARC, and DEFCAP. Together with RAIDD and PIDD/LRDD, caspase 2 has been shown to form the PIDDosome, which may serve as an activation platform for the protease, although it may also be activated in the absence of PIDD. Caspase 2 may also form a complex with the DNA-PKcs and PIDD/LRDD, which is involved in DNA repair after DNA damage.
Description:
Z-VDVAD-FMK is a synthetic peptide that irreversibly inhibits the activity of caspase-2. It attenuates oxyhemoglobin-induced cleavage of PARP and apoptosis in endothelial cells. Z-VDVAD-FMK can be used for both in vitro and in vivo studies--see note for using this product in vitro.
Synonym(s):
Z-VDVAD-fluoromethylketone; Caspase-2 Inhibitor (fluoromethylketone)
Purity:
≥90% by HPLC
Biological Activity:
We recommend using 2-10 µM for inhibiting caspase activity in cell culture. The optimal dose may vary for different cells and culture conditions.
Solubility:
Soluble in DMSO
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Notes:
The inhibitor is designed as a methyl ester to facilitate cell permeability. If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups.
Amino Acid Sequence:
Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-CH?F
Scientific Category:
Apoptosis Inhibitor
Product Type:
Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
