Bpsbioscience/VX-765/27779-2/10 mg
商品编号：
27779-2
品牌：
bpsbioscience
市场价：
¥3800.00
美元价：
2280.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW: 509 Da
CAS Registry #: 273404-37-8
Formula: C24H33ClN4O6
Target: Caspase1
Background:
VX-765 is an orally-absorbed pro-drug of VRT-043198, a potent and selective inhibitor of ICE/caspase-1 sub-family caspases. VRT-043198 exhibits 100-10,000-fold selectivity against other caspase-3 and -6-9. In cultures of peripheral blood mononuclear cells and whole blood from healthy subjects stimulated with bacterial products, VRT-043198 inhibited the release of Interleukin (IL)-1beta and IL-18, but had little effect on the release of several other cytokines, including IL-1alpha, tumor necrosis factor-alpha, IL-6 and IL-8. VX-765 has been shown to inhibit acute seizures in preclinical models of acute epilepsy and has shown activity in preclinical models of chronic epilepsy that do not respond to standard anti-epileptic drugs.
Description:
VX-765 is a novel Caspase-1 inhibitor being investigated for the treatment of epilepsy.
Synonym(s):
VX-765; VX765; Belnacasan; (2S)-1-[(2S)-2-[(4-amino-3-chlorobenzoyl)amino]-3,3-dimethylbutanoyl]-N-[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]pyrrolidine-2-carboxamide
Solubility:
Soluble in DMSO
Storage / Stability:
Store desiccated at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s):
1. Boxer MB, et al. ChemMedChem. 2010 May 3;5(5):730-8.
2. Wannamaker W, et al. J Pharmacol Exp Ther. 2007 May;321(2):509-16.
2. Wannamaker W, et al. J Pharmacol Exp Ther. 2007 May;321(2):509-16.
Warning(s):
Protect from moisture.
Scientific Category:
Apoptosis Inhibitor
Product Type:
Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
