Bpsbioscience/TW-37/27775-1/10毫克
商品编号：
27775-1
品牌：
bpsbioscience
市场价：
¥4200.00
美元价：
2520.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW: 573.7 Da
CAS Registry #: 877877-35-5
Formula: C33H35NO6S
Target: Bcl2
Background:
TW-37 is a Bcl-2 inhibitor that has been shown to inhibit the angiogenic potential of endothelial cells in vitro. S-phase arrest and apoptosis in pancreatic cancer cell lines have been observed to be induced by TW-37. It binds to the Bcl-2 homology domain 3 (BH3) groove of Bcl-2 preventing the heterodimerization of proapoptotic proteins (such as Bid, Bim, and Bad) with Bcl-2 and subsequently allowing them to induce apoptosis. Recent studies indicate TW-37 is able to inhibit the growth of a broad range of cancer cells (such as breast, prostate, lymphoma, and pancreatic cancer), since it induces S-phase cell cycle arrest with regulation of several important cell cycle related genes, including p27, p57, E2F-1, cdc25A, CDK4, cyclin A, cyclin D1 and cyclin E.
Description:
TW-37 is a potent small-molecule inhibitor that attenuates Bcl-2 activation and inhibits multiple Bcl-2 family members including Bcl-xL and Mcl-1. TW-37 also inhibits in vivo and in vitro the activation of Jagged-1 and Notch-1.
Synonym(s):
TW37; N-[4-(2-tert-butylphenyl)sulfonylphenyl]-2,3,4-trihydroxy-5-[(2-propan-2-ylphenyl)methyl]benzamide
Biological Activity:
TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 µM, 1.11 µM and 0.26 µM, respectively. Bcl-2: IC50 = 0.2 µM (human); Bcl-XL: IC50 = 6.58 µM (human); Mcl-1: IC50 = 1.03 µM
Solubility:
Soluble in DMSO (100 mM), ethanol (5 mM), and water (<1 mg/ml).
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s):
1. Wang, Z., et al. Cancer Res 2009;69:2757-2765.
2. Ashimori, N., et al. Mol Cancer Ther 2009;8:893-903.
2. Ashimori, N., et al. Mol Cancer Ther 2009;8:893-903.
Scientific Category:
Apoptosis Inducers
Product Type:
Activator/Inducer
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
