Bpsbioscience/TW-37/27775-2/50毫克
商品编号：
27775-2
品牌：
bpsbioscience
市场价：
¥10800.00
美元价：
6480.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:573.7Da
CASRegistry#:877877-35-5
Formula:C33H35NO6S
Target:Bcl2
Background:
TW-37isaBcl-2inhibitorthathasbeenshowntoinhibittheangiogenicpotentialofendothelialcellsinvitro.S-phasearrestandapoptosisinpancreaticcancercelllineshavebeenobservedtobeinducedbyTW-37.ItbindstotheBcl-2homologydomain3(BH3)grooveofBcl-2preventingtheheterodimerizationofproapoptoticproteins(suchasBid,Bim,andBad)withBcl-2andsubsequentlyallowingthemtoinduceapoptosis.RecentstudiesindicateTW-37isabletoinhibitthegrowthofabroadrangeofcancercells(suchasbreast,prostate,lymphoma,andpancreaticcancer),sinceitinducesS-phasecellcyclearrestwithregulationofseveralimportantcellcyclerelatedgenes,includingp27,p57,E2F-1,cdc25A,CDK4,cyclinA,cyclinD1andcyclinE.
Description:
TW-37isapotentsmall-moleculeinhibitorthatattenuatesBcl-2activationandinhibitsmultipleBcl-2familymembersincludingBcl-xLandMcl-1.TW-37alsoinhibitsinvivoandinvitrotheactivationofJagged-1andNotch-1.
Synonym(s):
TW37;N-[4-(2-tert-butylphenyl)sulfonylphenyl]-2,3,4-trihydroxy-5-[(2-propan-2-ylphenyl)methyl]benzamide
BIOLOGicalActivity:
TW-37isanovelnonpeptideinhibitortorecombinantBcl-2,Bcl-xLandMcl-1withKiof0.29µM,1.11µMand0.26µM,respectively.Bcl-2:IC50=0.2µM(human);Bcl-XL:IC50=6.58µM(human);Mcl-1:IC50=1.03µM
Solubility:
SolubleinDMSO(100mM),ethanol(5mM),andwater(<1mg/ml).
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.Wang,Z.,etal.CancerRes2009;69:2757-2765.
2.Ashimori,N.,etal.MolCancerTher2009;8:893-903.
2.Ashimori,N.,etal.MolCancerTher2009;8:893-903.
ScientificCategory:
ApoptosisInducers
ProductType:
Activator/Inducer
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
