Bpsbioscience/Tenovin-1/27660-2/50毫克
商品编号：
27660-2
品牌：
bpsbioscience
市场价：
¥4700.00
美元价：
2820.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:369.5Da
CASRegistry#:380315-80-0
Formula:C20H23N3O2S
Target:SIRT1,SIRT2
Background:
Tenovin-1,asmallmoleculediscoveredbyacell-basedscreen,isabio-activeactivatorofp53thatelevatesthelevelsofp53protein,p53-downstreamtargetp21CIP/WAF1proteinandmRNAandprotectsp53frommdm2-mediateddegradationwithlittleimpactonp53synthesis.Tenovin-1alsoexertsinhibitionagainsthumansirtuin1(SIRT1)andsirtuin2(SIRT2),twoimportantmembersofthesirtuinfamily.Tenovin-1repressescellgrowth,andinducesapoptosisinapaneloftumorcellsexpressingp53.Animprovedandwater-solubleversionoftenovin-1hasbeenfoundtodecreasethepeptidedeacetylaseactivityofhumanSIRT1andSIRT2withIC50valuesof21µMand10µMrespectively.
Description:
Tenovin-1inhibitstheprotein-deacetylatingactivitiesofSIRT1andSIRT2.Tenovin-1isalsoap53activatorandelevatestheamountofp53proteinwithin2hroftreatment,withoutalteringp53mRNAlevels.Tenovin-1protectsagainstMDM2-mediatedp53degradationviaubiquitination.
Synonym(s):
N-[(4-acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide
Purity:
≥99%byHPLC
Solubility:
SolubleinDMSO74mg/ml(200mM),or15%Captisol(modifiedcyclodextrin)15mg/ml.Solubilityinwaterorethanolis<1mg/ml(<1mM)
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
LainS,etal.CancerCell.2008May;13(5):454-63.
ScientificCategory:
DeacetylaseInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
