Bpsbioscience/SGI-1776游离碱/27651-1/5 mg
商品编号：
27651-1
品牌：
bpsbioscience
市场价：
¥3100.00
美元价：
1860.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW: 405.4 Da
CAS Registry #: 1025065-69-3
Formula: C20H22F3N5O
Target: Pim1
Background:
According to preliminary results from studies treating prostate cancer cells, SGI-1776 dose-dependently reduces phosphorylation of known Pim kinase substrates involved in cell cycle progression and apotosis (p21Cip1/WAF1 and Bad), compromises overall cell viability by inducing G1 cell cycle arrest and triggering apoptosis, and reduces cell viability in a multidrug resistance 1 (MDR1) protein based taxane-refractory prostate cancer cell line.
Description:
SGI-1776 is a potent ATP-competitive inhibitor of the serine/threonine family of Pim kinase, an enzyme regulating cell survival. Through extensive biomedical characterization, SGI-1776 exhibits specificity to the three isoforms of the Pim family, including Pim-1, Pim-2, and Pim-3. Treatment with SGI-1776 induces apoptosis in CLL primary cell line.
Synonym(s):
N-[(1-methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine
Purity:
≥98% by HPLC
Biological Activity:
SGI-1776 inhibits Pim1, Pim2, Pim3, and FLT3 with IC50 values of 7 nM, 363 nM, 69 nM, and 44nM respectively.
Solubility:
Soluble in DMSO
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s):
1. Mumenthaler, SM., et al. Mol Cancer Ther. 2009; 8(10): 2882-2893.
2. Lisa S. Chen, LS et al. Blood. 2009; 114(19): 4150-4157.
2. Lisa S. Chen, LS et al. Blood. 2009; 114(19): 4150-4157.
Scientific Category:
Kinase Inhibitors
Product Type:
Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
