Bpsbioscience/SGI-1776 free base/27651-2/10 mg
商品编号：
27651-2
品牌：
bpsbioscience
市场价：
¥4700.00
美元价：
2820.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:405.4Da
CASRegistry#:1025065-69-3
Formula:C20H22F3N5O
Target:Pim1
Background:
Accordingtopreliminaryresultsfromstudiestreatingprostatecancercells,SGI-1776dose-dependentlyreducesphosphorylationofknownPimkinasesubstratesinvolvedincellcycleprogressionandapotosis(p21Cip1/WAF1andBad),compromisesoverallcellviABIlitybyinducingG1cellcyclearrestandtriggeringapoptosis,andreducescellviabilityinamultidrugresistance1(MDR1)proteinbasedtaxane-refractoryprostatecancercellline.
Description:
SGI-1776isapotentATP-competitiveinhibitoroftheserine/threoninefamilyofPimkinase,anenzymeregulatingcellsurvival.Throughextensivebiomedicalcharacterization,SGI-1776exhibitsspecificitytothethreeisoformsofthePimfamily,includingPim-1,Pim-2,andPim-3.TreatmentwithSGI-1776inducesapoptosisinCLLprimarycellline.
Synonym(s):
N-[(1-methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine
Purity:
≥98%byHPLC
BIOLOGicalActivity:
SGI-1776inhibitsPim1,Pim2,Pim3,andFLT3withIC50valuesof7nM,363nM,69nM,and44nMrespectively.
Solubility:
SolubleinDMSO
Storage/Stability:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.Mumenthaler,SM.,etal.MolCancerTher.2009;8(10):2882-2893.
2.LisaS.Chen,LSetal.Blood.2009;114(19):4150-4157.
2.LisaS.Chen,LSetal.Blood.2009;114(19):4150-4157.
ScientificCategory:
KinaseInhibitors
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
