Bpsbioscience/Q-VD-OPh hydrate/27641-2/10 mg
商品编号：
27641-2
品牌：
bpsbioscience
市场价：
¥6160.00
美元价：
3696.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:513.49Da
CASRegistry#:1135695-98-5
Formula:C26H25F2N3O6•xH2O
Target:pan-caspase
Background:
Q-VD-OPhisabroadspectrumcaspaseinhibitorthatprovidesacosteffective,nontoxic,andhighlyspeci?cmeansofapoptoticinhibitionandprovidesnewinsightintothedesignofnewinhibitors.Itismorestableinaqueousenvironmentsandexhibitsseveralfoldshigheractivitythanthewidelyusedinhibitors,ZVAD-FMKandBoc-D-FMK.Q-VD-OPhisalsoequallyeffectiveinpreventingapoptosismediatedbythethreemajorapoptoticpathways,caspase9/3,caspase8/10,andcaspase12.Itcaninhibitrecombinantcaspases1,3,8,and9withIC50valuesrangingfrom25to400nM,andhasbeenshowntostronglyinhibitcaspases7,10,and12athigherconcentrations(10µM).Q-VD-OPhprotectedagainstthesubstantialapoptosisinducedbyactinomycinD.Inaddition,Q-VD-OPhaloneexhibitslittleornotoxicity,evenatextremelyhighconcentrations.
Description:
Q-VD-OPHisasecond-generationcapaseinhibitorthatishighlypotent,brainandcellpermeable,irreversIBLeandnontoxic.Q-VD-OPHcaninhibitcaspase-3(IC50=25nm),caspase-1(IC50=50nM),caspase-8(IC50=100nM)andcaspase-9(IC50=430nM).Inordertoreducehydrophobicityofthepeptideandtofacilitatetheuseinaqueousmedia,theaspartylresidueoftheinhibitorisnoto-methylated.
Synonym(s):
Q-VD-OPh;Quinolyl-Val-Asp-Oph
Purity:
≥96%byHPLC
Solubility:
SolubleinDMSO(10mM)
Format:
whitetolightbrownpowder
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
AminoAcidSequence:
Quinolyl-IE(OMe)-TD(OMe)-OPh
ScientificCategory:
ApoptosisInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
