Bpsbioscience/Q-VD-OPh hydrate/27641-1/5 mg
商品编号：
27641-1
品牌：
bpsbioscience
市场价：
¥4100.00
美元价：
2460.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW: 513.49 Da
CAS Registry #: 1135695-98-5
Formula: C26H25F2N3O6 • xH2O
Target: pan-caspase
Background:
Q-VD-OPh is a broad spectrum caspase inhibitor that provides a cost effective, non toxic, and highly speci?c means of apoptotic inhibition and provides new insight into the design of new inhibitors. It is more stable in aqueous environments and exhibits several folds higher activity than the widely used inhibitors, ZVAD-FMK and Boc-D-FMK. Q-VD-OPh is also equally effective in preventing apoptosis mediated by the three major apoptotic pathways, caspase 9/3, caspase 8/10, and caspase 12. It can inhibit recombinant caspases 1, 3, 8, and 9 with IC50 values ranging from 25 to 400 nM, and has been shown to strongly inhibit caspases 7, 10, and 12 at higher concentrations (10 µM). Q-VD-OPh protected against the substantial apoptosis induced by actinomycin D. In addition, Q-VD-OPh alone exhibits little or no toxicity, even at extremely high concentrations.
Description:
Q-VD-OPH is a second-generation capase inhibitor that is highly potent, brain and cell permeable, irreversible and nontoxic. Q-VD-OPH can inhibit caspase-3 ( IC50=25 nm), caspase-1 (IC50=50 nM), caspase-8 (IC50=100 nM) and caspase-9 (IC50=430 nM). In order to reduce hydrophobicity of the peptide and to facilitate the use in aqueous media, the aspartyl residue of the inhibitor is not o-methylated.
Synonym(s):
Q- VD-OPh; Quinolyl-Val-Asp-Oph
Purity:
≥96% by HPLC
Solubility:
Soluble in DMSO (10 mM)
Format:
white to light brown powder
Storage / Stability:
Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Amino Acid Sequence:
Quinolyl-IE(OMe)-TD(OMe)-OPh
Scientific Category:
Apoptosis Inhibitor
Product Type:
Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
