Bpsbioscience/Elesclomol (STA-4783)/27748-2/10 mg
商品编号：
27748-2
品牌：
bpsbioscience
市场价：
¥5800.00
美元价：
3480.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:400.5Da
CASRegistry#:488832-69-5
Formula:C19H20N4O2S2
Target:HSP90
Background:
Elesclomol(alsoknownasSTA-4783),originallyidentifiedinacell-basedphenotypicscreenforproapoptoticactivity,isanovelsmall-moleculethatpotentlyinducesapoptosisofcancercellsthroughtherapidgenerationofreactiveoxygenspecies(ROS)andtheinductionofunmanageablelevelsofoxidativestress.ElesclomolexhibitsautitumoractivityagainstabroadspectrumoftypesofcancercellinhumantumorxengograftmodelsduetoitsexcessiveROSproductionandelevatedlevelsofoxidativestressleADIngtothedeathofcancercells.Elesclomoliscurrentlybeingstudiesasanovelcancertherapeutic,inwhichithasdemonstratedABIlitytoprolongprogression-freesurvivalinstudysubjects.Elesclomolinducesoxidativestressbyprovokingabuildupofreactiveoxygenspecieswithincancercells.Elesclomolrequiresaredoxactivemetaliontofunction;theCu(II)complexis34timesmorepotentthantheNi(II)complexand1040-foldmorepotentthanthePt(II)complex.
Description:
Elesclomolinducesoxidativestressandtriggersmitochondrial-inducedapoptosisincancercells.
Synonym(s):
Elesclomol;STA-4783;STA4783
Solubility:
SolubleinDMSO
Storage/Stability:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.Blackman,RK,etal.PLoSONE2012;7(1):e29798
2.Kirshner,JR.,etal.MolCancerTher2008;7:2319-2327
2.Kirshner,JR.,etal.MolCancerTher2008;7:2319-2327
ScientificCategory:
ApoptosisInducers
ProductType:
Activator/Inducer
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
