Bpsbioscience/木豆内酯/27745-1/5 mg
商品编号：
27745-1
品牌：
bpsbioscience
市场价：
¥2160.00
美元价：
1296.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:232.3Da
CASRegistry#:553-21-9
Formula:C15H20O2
Description:
Costunolideisasesquiterpenelactonewithanti-oxidantpropertiesthatisfoundinlettuceandotherplants.Itiswidelyusedinmanyherbalmedicines.Costunolideisapotentinducerofapoptosis,apotentanti-canceragent,hasanti-inflammatory,anti-viral,anti-fungal,antimycobacterialactivityandhasbeenshowntoinhibittelomeraseactivity.
Synonym(s):
(+)-Costunolide;Costunolid;Costuslactone;NSC106404
BIOLOGicalActivity:
Costunolideisaninhibitorofhumantelomeraseactivity(IC50=65µMinMCF-7breastcancercells).Suppressesproliferationandinducesapoptosisinavarietyofhumantumorcelllines.SelectivelyblocksendothelialcellproliferationinducedbyVEGFandinhibitstheVEGFRKDR/Flk-1signalingpathway.InhibitsexpressionofiNOSandIL-1βanddisruptsNF-?Bactivation.ExposureofT24cellstocostunolidewasassociatedwithincreasedexpressionofBax,down-regulationofBcl-2,survivinandsignificantactivationofcaspase-3,anditsdownstreamtargetPARP.
Solubility:
SolubleinDMSO
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.Parketal(1996).J.Nat.Prod.591128.
2.Jeongetal(2002).CancerLett.187129.
3.Choietal(2005).CancerLett.227153.
2.Jeongetal(2002).CancerLett.187129.
3.Choietal(2005).CancerLett.227153.
ScientificCategory:
ApoptosisInducers
ProductType:
Activator/Inducer
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
