Bpsbioscience/IWP-L6/27755-1/10毫克
商品编号：
27755-1
品牌：
bpsbioscience
市场价：
¥3400.00
美元价：
2040.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:472.6Da
CASRegistry#:1427782-89-5
Formula:C25H20N4O2S2
Target:Porcupine
Background:
WP-L6wasdevelopedasasub-nanomolarinhibitorofPorcupine,theenzymethatcatalyzesthepalmitoylationofWntproteins.InHEK293cells,IWP-L6isfoundtosignificantlyinhibitthephosphorylationofdishevelled2(Dvl2).IWP-L6hasgoodstABIlityinhumanplasmabutweakerstabilityinratandmouseplasma.InvivoassayshowsthatIWP-L6isquiteactiveinzebrafish.Itblockstheregenerationofthetailfineffectively.Italsoshowsinhibitionofposterioraxisformationatlowmicromolarconcentrations.Additionally,inculturedmouseembryonickidneys,10nMIWP-L6cansignificantlyreducebranchingmorphogenesiswhile50nMIWP-L6completelyblocksWntsignaling.
Description:
IWP-L6isaninhibitorofPorcupinewithIC50valueof0.5nM.
Synonym(s):
2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(5-phenylpyridin-2-yl)acetamide
Solubility:
SolubleinDMSO
Storage/Stability:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
WangX,etal.JMedChem.2013Mar28;56(6):2700-4.
ScientificCategory:
WntSignaling
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
