Bpsbioscience/ICG 001/27752-1/10 mg
商品编号：
27752-1
品牌：
bpsbioscience
市场价：
¥3500.00
美元价：
2100.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:548.6Da
CASRegistry#:847591-62-2
Formula:C33H32N4O4
Background:
ICG001selectivelyinhibitscoloncarcinomacelllines(SW480andHCT-116cells)butnotnormalcolonicepithelialcells(CCD-841Co).ItisalsoefficaciousintheMinmouseandnudemousexenograftmodelsofcoloncancer.ICG-001isapotentinhibitorofGBMstemcellsinculture.ICG001selectivelyinhibitsWnt/beta-catenin/CREBbindingprotein(CBP)signalingtoreversespulmonaryfibrosisandameliorateexperimentaldermalfibrosisinexperimentalmodels.ICG001iscurrentlyinclinicaltrialsforcoloncancerandleukemias.
Description:
CG001isasmallmoleculeinhibitorthattargetsWnt/β-cateninpathway.ItinhibitsTCF/β-cateninmediatedtranscriptionbycompetingwithβ-cateninforCBP(CREBbindingprotein)butnotp300bindingwithanIC50of3µM.ItcanbeusedtospecificallyevaluatetheroleofCBP/beta-cateninassociationonWNTsignalingandcellphysiology.
Synonym(s):
(6S,9aS)-N-benzyl-6-[(4-hydroxyphenyl)methyl]-8-(naphthalen-1-ylmethyl)-4,7-dioxo-3,6,9,9a-tetrahydro-2H-pyrazino[1,2-a]pyrimidine-1-carboxamide
Solubility:
SolubleinDMSO
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.EmamiKH,etal.Proc.Natl.Acad.Sci.USA2004Aug24;101(34):12682-7.
2.HendersonWRJr.,etal.Proc.Natl.Acad.Sci.USA2010Aug10;107(32):14309-14.
3.BeyerC,etal.AnnRheumDis.2013Jul;72(7):1255-8.
2.HendersonWRJr.,etal.Proc.Natl.Acad.Sci.USA2010Aug10;107(32):14309-14.
3.BeyerC,etal.AnnRheumDis.2013Jul;72(7):1255-8.
ScientificCategory:
WntSignaling
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
