Bpsbioscience/ICG 001/27752-3/25 mg
商品编号：
27752-3
品牌：
bpsbioscience
市场价：
¥6600.00
美元价：
3960.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW: 548.6 Da
CAS Registry #: 847591-62-2
Formula: C33H32N4O4
Background:
ICG001 selectively inhibits colon carcinoma cell lines (SW480 and HCT-116 cells) but not normal colonic epithelial cells (CCD-841Co). It is also efficacious in the Min mouse and nude mouse xenograft models of colon cancer. ICG-001 is a potent inhibitor of GBM stem cells in culture. ICG001 selectively inhibits Wnt/beta-catenin/CREB binding protein (CBP) signaling to reverses pulmonary fibrosis and ameliorate experimental dermal fibrosis in experimental models. ICG001 is currently in clinical trials for colon cancer and leukemias.
Description:
CG001 is a small molecule inhibitor that targets Wnt/β-catenin pathway. It inhibits TCF/β-catenin mediated transcription by competing with β-catenin for CBP (CREB binding protein) but not p300 binding with an IC50 of 3 µM. It can be used to specifically evaluate the role of CBP/beta-catenin association on WNT signaling and cell physiology.
Synonym(s):
(6S,9aS)-N-benzyl-6-[(4-hydroxyphenyl)methyl]-8-(naphthalen-1-ylmethyl)-4,7-dioxo-3,6,9,9a-tetrahydro-2H-pyrazino[1,2-a]pyrimidine-1-carboxamide
Solubility:
Soluble in DMSO
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s):
1. Emami KH, et al. Proc. Natl. Acad. Sci. USA 2004 Aug 24;101(34):12682-7.
2. Henderson WR Jr., et al. Proc. Natl. Acad. Sci. USA 2010 Aug 10;107(32):14309-14.
3. Beyer C, et al. Ann Rheum Dis. 2013 Jul;72(7):1255-8.
2. Henderson WR Jr., et al. Proc. Natl. Acad. Sci. USA 2010 Aug 10;107(32):14309-14.
3. Beyer C, et al. Ann Rheum Dis. 2013 Jul;72(7):1255-8.
Scientific Category:
Wnt Signaling
Product Type:
Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
