Bpsbioscience/1,10-Phenanthroline, Monohydrate/27713/0.5 ml
商品编号：
27713
品牌：
bpsbioscience
市场价：
¥4100.00
美元价：
2460.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:198.2Da
CASRegistry#:5144-89-8
Formula:C12H8N2·H2O
Description:
1,10-phenanthroline(o-phenanthroline)isachelatorwithhighaffinityfordivalentmetalions.Whencomplexedwithcopper,itpossessesnucleaseactivitythathasbeenusedtostudyDNA-proteininteractions.WhilenotspecificforDUBs,ithasbeenshowntobeapotentinhibitorofJAMM-typeisopeptidasesthroughchelationoftheactivesiteZn2+ion.Assuch,o-phenanthrolineiswidelyusedwhenpreparingcelllysatesforenrichmentofproteinsbearingK63-linkedpolyubiquitinchainswhichareespeciallysensitivetoDUBsintheJAMMfamily.
Synonym(s):
o–phenanthroline
Purity:
≥99%
SuppliedAs:
0.5MsolutioninanhydrousDMSO(100X)
BIOLOGicalActivity:
Metalloproteaseinhibitor;chelatesiron,zincandotherdivalentmetals.Effectiveconcentration1-10mM.
Format:
DMSOsolution
Application(s):
UsefulforinhibitionofJAMM-familyisopeptidases.EspeciallyvaluableforprotectingK63-linkedpolyubiquitinchainsincelllysates.
Reference(s):
1.Cooper,E.M.,Cutcliffe,C.,Kristiansen,T.Z.,Pandey,A.,Pickart,C.M.,andCohen,R.E.(2009)K63-specificdeubiquitinationbytwoJAMM/MPN+complexes:BRISC-associatedBrcc36andproteasomalPoh1.EMBOJ.28:621-631.
2.Sigman,D.S.,etal.,Nucleaseactivityof1,10-phenanthroline-copperinstudyofproteinDNAinteractions.MethodsEnzymol.,208:414-433(1991).
2.Sigman,D.S.,etal.,Nucleaseactivityof1,10-phenanthroline-copperinstudyofproteinDNAinteractions.MethodsEnzymol.,208:414-433(1991).
Warning(s):
Protectfrommoisture.Avoidfreeze/thawcycles.
ScientificCategory:
UbiquitinEnzymes
ProductType:
Inhibitors/Activators
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
