Bpsbioscience/AT13387/27736-2/10 mg
商品编号：
27736-2
品牌：
bpsbioscience
市场价：
¥4800.00
美元价：
2880.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:409.5Da
CASRegistry#:912999-49-6
Formula:C24H31N3O3
Target:HSP90
Description:
AT13387,discoveredbyahigh-throughputx-raycraystallographyfragment-basedplatform,isanon-geldanamycininhibitorofheatshockproterin90(HPS90),amoleculechaperoneregulatingsignaltransductionpathwaysforcellgrowthandsurvival.IthashighaffinityforbindingHSP90(Kd=0.5nM)andexhibitedaninvitrocytotoxicityshowingamedianEC50valueof41nM.TheantitumoractivityofAT13387againstsolidtumorandleukemiamodelsissimilartoalvespimycin.
Synonym(s):
(2,4-dihydroxy-5-propan-2-ylphenyl)-[5-[(4-methylpiperazin-1-yl)methyl]-1,3-dihydroisoindol-2-yl]methanone
BIOLOGicalActivity:
AT13387isapotentinhibitoroftheproliferationandsurvivalofmanydifferentcelllines(suchasMES-SAcellline)fromavarietyofdifferenttumortypes.Acrossapanelof30tumorcelllines,AT13387potentlyinhibitscellproliferationwithGI50valuesintherange13-260nM.AT13387inhibitsproliferationofthenon-tumOrigenichumanprostateepithelialcelllinePNT2withaGI50valueof480nM.TheinhibitionofanumberofisolatedkinasesbyAT13387isalsoinvestigatedincludingCDK1,CDK2,CDK4,FGFR3,PKB-b,JAK2,VEGFR2,PDGFRβandAuroraB.Noneofthetestedkinasesaresignificantlyinhibitedatconcentrationsbelow30µM.
Solubility:
SolubleinDMSO
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
MinH.etal.PediatrBloodCancer.2012;59(1):185-188.
ScientificCategory:
HSPInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
