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当前位置: 首页 > 产品中心 > cytokine > Bpsbioscience/UHRF1, His-FLAG-tags/55001/50 µg
商品详细Bpsbioscience/UHRF1, His-FLAG-tags/55001/50 µg
Bpsbioscience/UHRF1, His-FLAG-tags/55001/50 µg
Bpsbioscience/UHRF1, His-FLAG-tags/55001/50 µg
商品编号: 55001
品牌: bpsbioscience
市场价: ¥8800.00
美元价: 5280.00
产地: 美国(厂家直采)
公司:
产品分类: 细胞因子
公司分类: cytokine
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Species:Human
HostSpecies:Sf9insectcells
MW:92kDa
Genbank#:NM_001048201
Tag(s):N-terminalHis-FLAG-tags
a.a:2–793
Background:
MultidomainproteinthatactsasakeyepigeneticregulatorbybridgingDNAmethylationandchromatinmodification.SpecificallyrecognizesandbindshemimethylatedDNAatreplicationforksviaitsYDGdomainandrecruitsDNMT1methyltransferasetoensurefaithfulpropagationoftheDNAmethylationpatternsthroughDNAreplication.InadditiontoitsroleinmaintenanceofDNAmethylation,italsoplaysakeyroleinchromatinmodification.TheproteinbindstospecificDNAsequences,andrecruitsahistonedeacetylasetoregulategeneexpression.HasE3ubiquitin-proteinligaseactivitybymediatingtheubiquitinationoftargetproteinssuchashistoneH3andPML.MaybeinvolvedinDNArepair.ItsexpressionpeaksatlateG1phaseandcontinuesduringG2andMphasesofthecellcycle.ItplaysamajorroleintheG1/StransitionbyregulatingtopoisomeraseIIalphaandretinoblastomageneexpression,andfunctionsinthep53-dependentDNAdamagecheckpoint.AlsolocalizestoeuchromaticregionswhereitnegativelyregulatestranscriptionpossIBLybyimpactingDNAmethylationandhistonemodifications.
Description:

Humanubiquitin-likewithPHD,Tudor andringfingerdomains1(UHRF1),
GenBankAccessionNo.NM_001048201,a.a.2–793(end)with
N-terminalHis-Flagtag,MW=92kDa, expressedinaBaculovirusinfectedSf9
cellexpressionsystem.

UniProt
Q96T88
Synonym(s):
UHRF1,Ubiquitin-LikeWithPHDAndRingFingerDomains,RINGFingerProtein106,RNF106,Np95,ICBP90
Formulation:

40mMTris-HCl,pH8.0,110mMNaCl,2.2mMKCl,0.05%Tween-20,100μg/mlFlagpeptide,and20%glycerol.

Format:
Aqueousbuffersolution
Storage/StABIlity:

≥ 6monthsat-80°C

Application(s):
Usefulforproteinbindingassays,screeninginhibitors,andselectivityprofiling.
Reference(s):

1.Kofunato,Y., etal.,OncolRep.2012Dec; 28(6):1997-2002.
2.Jazirehi,A.R., etal.,Epigenomics.2012Jun;4(3):251-252.
3.Jenkins,Y., etal.,MolBiolCell.2005Dec;16(12):5621-9.

ApplicationReference(s):
Poly(ADP-ribose)polymerase1(PARP1)associateswithE3ubiquitin-proteinligaseUHRF1andmodulatesUHRF1BIOLOGicalfunctions(2014)

Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
Methyl-lysineReader,UbiquitinE3ligase
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介:为生命科学研究提供ELISA试剂盒(仅供科研)、抗体和抗原(仅供科研)、流式抗体,使您的检测结果更稳定可靠,用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀,吸附性好,空白值低,孔底透明度高,代做ELISA实验等。