Bpsbioscience/UHRF1（108-286），His标签/55004/100µg
商品编号：
55004
品牌：
bpsbioscience
市场价：
¥8800.00
美元价：
5280.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species:Human
HostSpecies:E.coli
MW:21.6kDa
Genbank#:NM_001048201
Tag(s):N-terminalHis-tag
a.a:108–286
Background:
MultidomainproteinthatactsasakeyepigeneticregulatorbybridgingDNAmethylationandchromatinmodification.SpecificallyrecognizesandbindshemimethylatedDNAatreplicationforksviaitsYDGdomainandrecruitsDNMT1methyltransferasetoensurefaithfulpropagationoftheDNAmethylationpatternsthroughDNAreplication.InadditiontoitsroleinmaintenanceofDNAmethylation,italsoplaysakeyroleinchromatinmodification.TheproteinbindstospecificDNAsequences,andrecruitsahistonedeacetylasetoregulategeneexpression.HasE3ubiquitin-proteinligaseactivitybymediatingtheubiquitinationoftargetproteinssuchashistoneH3andPML.MaybeinvolvedinDNArepair.ItsexpressionpeaksatlateG1phaseandcontinuesduringG2andMphasesofthecellcycle.ItplaysamajorroleintheG1/StransitionbyregulatingtopoisomeraseIIalphaandretinoblastomageneexpression,andfunctionsinthep53-dependentDNAdamagecheckpoint.AlsolocalizestoeuchromaticregionswhereitnegativelyregulatestranscriptionpossIBLybyimpactingDNAmethylationandhistonemodifications.
Description:
TandemTudorDomainregion(a.a.108-286)ofhumanubiquitin-likewithPHDandringfingerdomains1(UHRF1),GenBankAccession#NM_001048201,withN-terminalHis-tag,MW=21.6kDa,expressedinanE.colicellexpressionsystem.
UniProt
Q96T88
Synonym(s):
UHRF1,Ubiquitin-LikeWithPHDAndRingFingerDomains,RINGFingerProtein106,RNF106,Np95,ICBP90
Formulation:
40mMTris-HCl,pH8.0,110mMNaCl,2.2mMKCl,10mMβ-mercaptoethanol,250mMimidazole,and20%glycerol
Format:
Aqueousbuffersolution
Storage/StABIlity:
≥ 6monthsat-80°C
Application(s):
Usefulforproteinbindingassays,screeninginhibitors,andselectivityprofiling.
Reference(s):
1.Kofunato,Y., etal.,OncolRep.
2012Dec; 28(6):1997-2002.
2.Jazirehi,A.R., etal.,Epigenomics.
2012Jun;4(3):251-252.
ApplicationReference(s):
Poly(ADP-ribose)polymerase1(PARP1)associateswithE3ubiquitin-proteinligaseUHRF1andmodulatesUHRF1BIOLOGicalfunctions(2014)
Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
Methyl-lysineReader
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
