Bpsbioscience/UHRF1 (108-286), GST-tag/55003/100 µg
商品编号:
55003
品牌:
bpsbioscience
市场价:
¥8800.00
美元价:
5280.00
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Species:Human
HostSpecies:E.coli
MW:47.5kDa
Genbank#:NM_001048201
Tag(s):N-terminalGST-tag
a.a:108–286
Background:
MultidomainproteinthatactsasakeyepigeneticregulatorbybridgingDNAmethylationandchromatinmodification.SpecificallyrecognizesandbindshemimethylatedDNAatreplicationforksviaitsYDGdomainandrecruitsDNMT1methyltransferasetoensurefaithfulpropagationoftheDNAmethylationpatternsthroughDNAreplication.InadditiontoitsroleinmaintenanceofDNAmethylation,italsoplaysakeyroleinchromatinmodification.TheproteinbindstospecificDNAsequences,andrecruitsahistonedeacetylasetoregulategeneexpression.HasE3ubiquitin-proteinligaseactivitybymediatingtheubiquitinationoftargetproteinssuchashistoneH3andPML.MaybeinvolvedinDNArepair.ItsexpressionpeaksatlateG1phaseandcontinuesduringG2andMphasesofthecellcycle.ItplaysamajorroleintheG1/StransitionbyregulatingtopoisomeraseIIalphaandretinoblastomageneexpression,andfunctionsinthep53-dependentDNAdamagecheckpoint.AlsolocalizestoeuchromaticregionswhereitnegativelyregulatestranscriptionpossIBLybyimpactingDNAmethylationandhistonemodifications.
Description:
TandemTudorDomainregion(a.a.108-286)ofhumanubiquitin-likewithPHDandringfingerdomains1(UHRF1),GenBankAccession#NM_001048201,withN-terminalGST-tag,MW=47.5kDa,expressedinanE.colicellexpressionsystem.
UniProt
Q96T88
Synonym(s):
UHRF1,Ubiquitin-LikeWithPHDAndRingFingerDomains,RINGFingerProtein106,RNF106,Np95,ICBP90
Formulation:
40mMTris-HCl,pH8.0,110mMNaCl,2.2mMKCl,10mMβ-mercaptoethanol,20mMglutathione,and20%glycerol
Format:
Aqueousbuffersolution
Storage/StABIlity:
≥ 6monthsat-80°C
Application(s):
Usefulforproteinbindingassays,screeninginhibitors,andselectivityprofiling.
Reference(s):
1.Kofunato,Y.,etal.,OncolRep.2012Dec;28(6):1997-2002.
2.Jazirehi,A.R.,etal.,Epigenomics.2012Jun;4(3):251-252.
ApplicationReference(s):
Poly(ADP-ribose)polymerase1(PARP1)associateswithE3ubiquitin-proteinligaseUHRF1andmodulatesUHRF1BIOLOGicalfunctions(2014)
Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
Methyl-lysineReader
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介:为生命科学研究提供ELISA试剂盒(仅供科研)、抗体和抗原(仅供科研)、流式抗体,使您的检测结果更稳定可靠,用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀,吸附性好,空白值低,孔底透明度高,代做ELISA实验等。