Bpsbioscience/IDH1（R132H）检测试剂盒/79376/96反应
商品编号：
79376
品牌：
bpsbioscience
市场价：
¥10200.00
美元价：
6120.00
产品分类：
其它检测试剂盒
公司分类：
Other_kits
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Background:
Isocitratedehydrogenasesareenzymesthatcatalyzetheoxidativedecarboxylationofisocitrateto2-oxoglutarate.Mutationsinisocitratedehydrogenases1and2(IDH1andIDH2)havebeenreportedinamultitudeofhumancancers.WhilethewildtypeIDH1,producesα-ketoglutarate(α-KG)throughthereductionofNADP+toNADPH,theIDH1(R132H)mutantcatalyzesconversionofα-ketoglutarateto2-hydroxy-glutarate(2-HG)byoxidizingNADPHtoNADP+.GenomicstudieshaveidentifiedtheIDH1(R132H)mutationinvariouscancertypes,includingglioma,chondrosarcoma,andAMLaswellasasmallpercentageofprostate,lungandcoloncancers.
Description:
TheIDH1(R132H)AssayKitisdesignedtomeasureIDH1(R132H)activityforscreeningandprofilingapplicationsbymeasuringNADPHconsumption.
Synonym(s):
IsocitrateDehydrogenase1,IDH1,OxalosuccinateDecarboxylase,IDHM
SuppliedAs:
TheIDH1(R132H)AssayKitcomesinaconvenient96-wellformat,withenoughpurifiedrecombinantIDH1(R132H)enzyme,α-KG,NADPH,NADPHdetectionreagents,andassaybufferfor100enzymereactions.
Format:
Instructionsforuse:
Seeassaykitdatasheetfordetailedprotocol.
Storage/StABIlity:
Stableatleast6monthsfromdateofreceipt,whenstoredasdirected.Kitcomponentsrequiredifferentstorageconditions.Besuretostoreeachcomponentatthepropertemperatureuponarrival.
Application(s):
UsefulforscreeningsmallmolecularinhibitorsfordrugdiscoveryandHTSapplications.
Reference(s):
Wang,F.et.al.Science340:622-626(2013).
Warning(s):
Avoidfreeze/thawcycles.
ScientificCategory:
MetabolicEnzymes
ProductType:
AssayKit
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
