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当前位置: 首页 > 产品中心 > cytokine > Bpsbioscience/14-3-3 sigma Protein, His-tag (Human)/79037/20 μg
商品详细Bpsbioscience/14-3-3 sigma Protein, His-tag (Human)/79037/20 μg
Bpsbioscience/14-3-3 sigma Protein, His-tag (Human)/79037/20 μg
Bpsbioscience/14-3-3 sigma Protein, His-tag (Human)/79037/20 μg
商品编号: 79037
品牌: bpsbioscience
市场价: ¥7500.00
美元价: 4500.00
产地: 美国(厂家直采)
公司:
产品分类: 细胞因子
公司分类: cytokine
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Species:Human
HostSpecies:Sf9insectcellsusingbaculovirus
MW:30kDa
Genbank#:NM_006142
Tag(s):N-terminalHistag
a.a:Fulllength
Background:
14-3-3sigmaorstratifinisaproteinthatisstronglyinducedbygammairrADIationandotherDNA-damagingagents(1).Theinductionof14-3-3sigmaismediatedbyap53responsiveelement.Exogenousintroductionof14-3-3sigmaintocyclingcellsresultsinaG2cellcyclearrest(2).Knockoutof14-3-3sigmaincellsshowedthatthecellsareunabletomaintaincellcyclearrestafterDNAdamage.The14-3-3sigma-/-cellsdieastheyentermitosis.Thisprocessisassociatedwithafailureofthe14-3-3sigma-deficientcellstosequestertheproteinsthatinitiatemitosisandpreventthemfromenteringthenucleus.Thus,14-3-3sigmaplaysanimportantroleinmaintainingtheG2checkpointincellsandpreventingmitoticdeath.
Description:
Human14-3-3sigmaProtein,GenBankAccessionNo.NM_006142,fulllength,withN-terminalHis-tag,expressedinSf9insectcellsusingbaculovirus.MW=30kDa.
Synonym(s):
14-3-3sigma,SFN,stratifin,YWHAS
Formulation:
50mMsodiumphosphate,pH7.0,300mMNaCl,150mMimidazole,0.1mMPMSF,0.25mMDTT,25%glycerol
Storage/StABIlity:
Storeproductat–70°C.Foroptimalstorage,aliquottargetintosmallerquantitiesaftercentrifugationandstoreatrecommendedtemperature.Formostfavorableperformance,avoidrepeatedhandlingandmultiplefreeze/thawcycles.
Application(s):
Westernblot
Reference(s):
1.Chan,TA.etal:14-3-3-sigmaisrequiredtopreventmitoticcatastropheafterDNAdamage.Nature401:616-620,1999.

2.Hermeking,H.etal:14-3-3-sigmaisap53-regulatedinhibitorofG2/Mprogression.Molec.Cell1:3-11,1997.

ScientificCategory:
Kinase
ProductType:
Protein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介:为生命科学研究提供ELISA试剂盒(仅供科研)、抗体和抗原(仅供科研)、流式抗体,使您的检测结果更稳定可靠,用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀,吸附性好,空白值低,孔底透明度高,代做ELISA实验等。