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当前位置: 首页 > 产品中心 > cytokine > Bpsbioscience/14-3-3 alpha/beta Protein, His-tag (Human)/79023/20 μg
商品详细Bpsbioscience/14-3-3 alpha/beta Protein, His-tag (Human)/79023/20 μg
Bpsbioscience/14-3-3 alpha/beta Protein, His-tag (Human)/79023/20 μg
Bpsbioscience/14-3-3 alpha/beta Protein, His-tag (Human)/79023/20 μg
商品编号: 79023
品牌: bpsbioscience
市场价: ¥7500.00
美元价: 4500.00
产地: 美国(厂家直采)
公司:
产品分类: 细胞因子
公司分类: cytokine
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Species:Human
HostSpecies:E.coli
MW:32kDa
Genbank#:NM_003404
Tag(s):C-terminalHistag
a.a:FullLength
Background:
14-3-3alpha/betaisamemberofthehighlyconserved14-3-3familyofproteinswhichmediatesignaltransductionbybindingtophosphoserine-containingproteins(1).14-3-3alpha/betaproteinhasbeenshowntointeractwithRAF1andCDC25phosphatases,suggestingthatitmayplayaroleinlinkingmitogenicsignalingandthecellcyclemachinery.14-3-3-alpha/betainteractswiththeTSC1-TSC2dimer(2).TheinteractionrequiredphosphorylationofTSC2atSer1210.Bindingof14-3-3-alpha/betatoTSC2didnotaltertheinteractionbetweenTSC1andTSC2,butitreducedtheABIlityofthecomplextoinhibitphosphorylationofribosomalproteinS6kinaseimpairingtheabilityofthecomplextoinhibitcellgrowth.
Description:
Human14-3-3alpha/betaProtein,GenBankAccessionNo.NM_003404,fulllength,withC-terminalHistag,expressedinanE.coliexpressionsystem.MW=32kDa.
Synonym(s):
14-3-3alpha/beta,YWHAB,HS1,GW128,KCIP-1
Formulation:
50mMsodiumphosphate,pH7.0,300mMNaCl,150mMimidazole,0.1mMPMSF,0.25mMDTT,25%glycerol
Storage/Stability:
Storeproductat–70°C.Foroptimalstorage,aliquottargetintosmallerquantitiesaftercentrifugationandstoreatrecommendedtemperature.Formostfavorableperformance,avoidrepeatedhandlingandmultiplefreeze/thawcycles.
Application(s):
WesternBlot
Reference(s):
1.Yaffe,MB.etal:Thestructuralbasisfor14-3-3:phosphopeptidebindingspecificity.Cell91:961-971,1997.

2.Shumway,SD.etal:14-3-3-betabindstoandnegativelyregulatesthetuberoussclerosiscomplex2(TSC2)tumorsuppressorgeneproduct,tuberin.J.Biol.Chem.278:2089-2092,2003.

ScientificCategory:
Kinase
ProductType:
Protein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介:为生命科学研究提供ELISA试剂盒(仅供科研)、抗体和抗原(仅供科研)、流式抗体,使您的检测结果更稳定可靠,用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀,吸附性好,空白值低,孔底透明度高,代做ELISA实验等。