Bpsbioscience/（-）-JQ1/27334/5毫克
商品编号：
27334
品牌：
bpsbioscience
市场价：
¥3800.00
美元价：
2280.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:457.0kDa
CASRegistry#:1268524-71-5
Formula:
C23H25ClN4O2S
Background:
(-)-JQ1istheinactivestereoisomerofthepotent,cell-permeable,smallmoleculebromodomaininhibitor(+)-JQ1thatcompetitivelybindstoacetyl-lysinerecognitionmotifs.(+)-JQ1competitivelybindstothebromodomaindisplacingtheBRD4fusiononcoproteinfromchromatin,whichinducessquamousdifferentiationandspecificanti-proliferativeeffectinBRD4-dependentcelllinesandpatient-derivedxenograftmodels.However,studyresultshaveshownthat(-)-JQ1failstosignificantlyinteractwithanybromodomaintestedandexhibitsinhibitionagainstBRD4(1)withandIC50of10,000nM.
Synonym(s):
(R)-tert-butyl2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
BIOLOGicalActivity:
(-)-JQ1showednoinhibitionofBRD4-dependentNMCcells.
Solubility:
SolubleinDMSOorethanolat100mM
Storage/StABIlity:
Storeatorbelow-80°C.Stableforlessthan6monthswhenstoredasdirected.
Reference(s):
Filippakopoulos,P.,etal.Nature.2010Dec23;468(7327):1067-73.
ApplicationReference:
1.BETbromodomaininhibitorsblockgrowthofpancreaticcancercellsinthree-dimensionalcollagen(2014)
2.Dualkinase-bromodomaininhibitorsforrationallydesignedpolypharmacology(2014)
Warning(s):
Avoidfreeze/thawcycles.
ScientificCategory:
Bromodomain
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
