Bpsbioscience/(+)-JQ1/27402/5 mg-免疫在线蚂蚁淘旗下平台

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商品详细Bpsbioscience/(+)-JQ1/27402/5 mg

Bpsbioscience/(+)-JQ1/27402/5 mg

商品编号： 27402

品牌： bpsbioscience

市场价： ¥1900.00

美元价： 1140.00

产地：美国(厂家直采)

公司：

产品分类：细胞因子

公司分类： cytokine

联系Q Q： 3392242852

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商品介绍

MW:457.0Da

CASRegistry#:1268524-70-4

Formula:C₂₃H₂₅ClN₄O₂S

Description:

(+)-JQ1isaspecificinhibitoroftheBETfamilyofacetyl-lysinerecognitionmotifs,includingtheBRD2,BRD3,BRD4andBRDTbromodomains.

Synonym(s):

BETinhibitor,Bromodomaininhibitor

Purity:

≥95%byHPLC

BIOLOGicalActivity:

(+)-JQ1hasbeenshowntoinhibitBRD4(BD1)withaKdof50nM,andBRD4(BD2)withaKdof90nM.

Solubility:

SolubleinDMSOorethanol;insolubleinwater.

Format:

Acrystallinesolid.

Storage/StABIlity:

Storeatorbelow+4°C.Stableatleast6monthsfromdateofreceipt,whenstoredasdirected.

Reference(s):

Filippakopoulos,P., etal.,Nature. 468(7327):1067-73(2011).

ApplicationReference(s):
1. ThepolycombgroupproteinBMI-1inhibitorPTC-209isapotentanti-myelomaagentaloneorincombinationwithepigeneticinhibitorstargetingEZH2andtheBETbromodomains(2017)
2. AnalysisofChromatinOpeninginHeterochromaticNon-SmallcellLungCancerTumor-InitiatingCellsinRelationtoDNA-DamagingAntitumorTreatment (2017)
3. NotchInhibitionEnhancesCardiacReprogrammingbyIncreasingMEF2CTranscriptionalActivity (2017)
4. PanobinostatactssynergisticallywithibrutinibindiffuselargeBcelllymphomacellswithMyD88L265mutations (2017)
5. Erratum:BRD4isahistoneacetyltransferasethatevictsnucleosomesfromchromatin (2017)
6. TargetingBETproteinsimprovesthetherapeuticefficacyofBCL-2inhibitioninT-cellacutelymphoblasticleukemia (2017)
7. UncoveringBRD4hyperphosphorylationassociatedwithcellulartransformationinNUTmidlinecarcinoma (2017)
8. DeacetylaseinhibitorsrepressSTAT5-mediatedtranscriptionbyinterferingwithbromodomainandextra-terminal(BET)proteinfunction (2015)
9. GLI2-dependentc-MYCupregulationmediatesresistanceofpancreaticcancercellstotheBETbromodomaininhibitorJQ1 (2015)
10. BETbromodomaininhibitorsblockgrowthofpancreaticcancercellsinthree-dimensionalcollagen (2014)
11. Dualkinase-bromodomaininhibitorsforrationallydesignedpolypharmacology (2014)
12. BETbromodomainproteininhibitionisatherapeuticoptionformedulloblastoma (2013)

ScientificCategory:

Bromodomain

ProductType:

Inhibitor

Datashownislot-specific.Contactusforspecificinformationonotherlots.

品牌介绍

bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。

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