Bpsbioscience/HSP90β, His-tag/50292/200 µg
商品编号：
50292
品牌：
bpsbioscience
市场价：
¥7900.00
美元价：
4740.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species:Human
HostSpecies:E.coli
MW:83kDa
Genbank#:AY359878
Tag(s):C-terminalHis-tag
a.a:fulllength
Background:
Hsp90(90kDaheatshockprotein)isamolecularchaperonethataidsproteinfoldingandqualitycontrolforalargenumberofclientproteins.FunctionalHsp90operatesasdimerandhasintrinsicATPaseactivity.TheHsp90dimeractsinconcertwithotherchaperones(e.g.Hsp70)andisregulatedbyanumberofco-chaperones/accessoryproteins(e.g.Hop,cdc37).Hsp90hasbeenshowntointeractwith>100proteinsandsomenotableclientsincludekinases(e.g.Raf-1),nuclearhormonereceptors(e.g.estrogenreceptors),transcriptionfactors(e.g.p53),GPCRs(e.g.CB2receptors)andionchannels(e.g.CFTR).Inhumans,theHsp90betaisoformisconstitutivelyexpressedwhereastheHsp90alphaisoformsisexpressedunderstressconditions.Hsp90playsanimportantroleinsometumorcelltypesbystABIlisingmutatedoncogenicproteins.InhibitionofHsp90betafunctionhasbeenshowntoplayaroleintumOrigenesisanddiseaseprogression.
Description:
HumanHeatShockProtein90β(GenBankAccessionNo.AY359878),fulllengthwithC-terminalHis-tag,MW=83kDa,expressedinanE.coliexpressionsystem.
UniProt
P08238
Synonym(s):
HSP90b,HeatShockProtein90b,HSP90beta,HSP90β
AssayConditions:
AssayedusingtheBPSHsp90βAssaykit,Cat.#50294.
Formulation:
40mMTris-HCl,pH8.0,110mMNaCl,2.2mMKCl,2mMDTT,and20%glycerol.
Format:
Aqueousbuffersolution
Storage/Stability:
Atleast6monthsat–80°C.Avoidfreeze/thawcycles.Proteinmaybedilutedto≥100µg/mlinPBS+glycerolandstoredat-80°C.
Application(s):
Usefulforthestudyofenzymekinetics,screeninginhibitors,andselectivityprofiling.
Reference(s):
1.MilicevicZetal.,IntJOncol.2008Jun;32(6):1169-78.
2.ChaoC.C.etal.,JCellBiochem.2008Jul1;104(4):1286-96.
2.ChaoC.C.etal.,JCellBiochem.2008Jul1;104(4):1286-96.
Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
HeatShockProteins
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
