Bpsbioscience/AR-42（OSU-HDAC42）/27603-3/50毫克
商品编号：
27603-3
品牌：
bpsbioscience
市场价：
¥14200.00
美元价：
8520.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:312.4Da
CASRegistry#:935881-37-1
Formula:C18H20N2O3
Target:HDAC
Background:
AR-42induceshistoneH3acetylation,α-tubulinacetylationandp21up-regulation,whichhavebeenconsideredasthehallmarkindicatorsofHDACinhibition.AR-42hasbeenfoundtomodulateseveralapoptosisinhibitorsaswellascellsurvivalregulator,includingAkt,Bcl-xL,Bax,Ku70andsurviving,andexertpotentantitumoractivityagainstmultipletumortypes,suchashumanprostateandhepaticcancers,atleastpartiallythroughPI3K/Aktpathwayinhibition.AR-42hasbeendesignatedanorphandrugbytheFDAforthetreatmentofmeningiomaandschwannomaofthecentralnervoussystem.Meningiomaandschwannomaarerare,benigntumorsthatcanpresentindifferentlocationswithinthebrainandthespinalcordandmaycausesubstantialmorbidity.
Description:
AR-42(alsoknownasOSU-HDAC42),aderivativeofhydroxamate-tetheredphenylbutyrateisabroad-spectrumdeacetylaseinhibitorofbothhistoneandnon-histoneproteins.AR-42treatmentinduceshistonehyperacetylationandp21WAF/CIP1overexpression,inhibitsgp130/Stat3pathwayandinducesapoptosisandcellcyclearrestinmultiplemyelomacells.
Synonym(s):
OSU-HDAC42;N-hydroxy-4-[[(2S)-3-methyl-2-phenylbutanoyl]amino]benzamide
Purity:
≥99%byHPLC
BIOLOGicalActivity:
AR-42isapan-HDACinhibitorwithIC50of16-30nM.Ithasdemonstratedgreaterpotencyandactivityinsolidtumorsandhematologicalmalignancies(includingchroniclymphocyteleukemia,orCLL,B-celllymphoma,prostateandovariancancers)whencomparedtovorinostat(SAHA),thefirstoftwomarketedcompoundintheclass.
Solubility:
SolubleinDMSO
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.Burns,S.S.,etal.CancerRes.2013Jan15;73(2):792-803.
2.Zhang,S.,etal.IntJCancer.2011Jul1;129(1):204-13.
3.Lucas,D.M.,etal.PLoSOne.2010Jun3;5(6):e10941
2.Zhang,S.,etal.IntJCancer.2011Jul1;129(1):204-13.
3.Lucas,D.M.,etal.PLoSOne.2010Jun3;5(6):e10941
ScientificCategory:
DeacetylaseInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
