Bpsbioscience/Anti-PD-1 (S228P) Neutralizing Antibody/71326/100 µg
商品编号:
71326
品牌:
bpsbioscience
市场价:
¥9800.00
美元价:
5880.00
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Species:Human
HostSpecies:HEK293
MW:HeavyChain:50kDa,LightChain:25kDa
Tag(s):None
Clonality:Monoclonal
Isotype:IgG4
Background:
ThisantibodybindsandblockstheactivationofthePD-1receptor.Theantibodyishumanized,containingahumanIgG4Fcregionwithanengineeredhingeregionmutation(S228P)designedtopreventtheexchangeofIgG4molecules.ThisantibodyisequivalenttoNivolumab,whichhasbeenapprovedbytheFDAforthetreatmentofmelanomaandmetastaticsquamousnon-smallcelllungcancer.
Description:
Humanizedrecombinantanti-PD-1(IgG4)antibodywithS228Pmutation,expressedinHEK293cells.Thisantibodyhasnotbeentestedwithotherspecies.
Synonym(s):
PD-L1NeutralizingAntibody,ProgrammedCellDeath1Ligand1,PD1
SpecificActivity:
IC50=14nM
AssayConditions:
AntibodywasaddedtoPD-1:PD-L1[Biotinylated]bindingassayatvariousconcentrations.AssaywasperformedaccordingtotheprotocolinBPSCat.#72005or#72006,respectively.
Formulation:
8mMphosphate,pH7.4,110mMNaCl,2.2mMKCl,and20%glycerol.
Purification:
ProteinAaffinitychromatographyfromHEK293supernatants.
Format:
Aqueousbuffersolution.
Storage/StABIlity:
Stableforatleast12monthsat-80°C.
Application(s):
UsefulforinhibitionofPD-1:PD-L1andPD-1:PD-L2interactionsandforwesternblotanalysis.
Reference(s):
1.Shinohara,T.,etal.,Genomics.1994;23(3):704-6.
2.James,E.S.,etal.,GenesImmun.2005;6(5):430-7.
Warning(s):
Avoidfreeze/thawcycles.Storedilutedantibodywithcarrierprotein(BSA0.1–0.5%)at4°C,stablefor2weeks.
ScientificCategory:
Immunotherapy
ProductType:
Antibody
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介:为生命科学研究提供ELISA试剂盒(仅供科研)、抗体和抗原(仅供科研)、流式抗体,使您的检测结果更稳定可靠,用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀,吸附性好,空白值低,孔底透明度高,代做ELISA实验等。