Bpsbioscience/抗PCSK9中和抗体/71207/50µg
商品编号：
71207
品牌：
bpsbioscience
市场价：
¥9800.00
美元价：
5880.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species:Human
HostSpecies:Freestyle293cells
MW:~150kDa
Tag(s):none
Clonality:Monoclonal(human)
Isotype:IgG1
Background:
PCSK9isacrucialplayerintheregulationofplasmacholesterolhomeostasis.Itbindstolow-densitylipidreceptorfamilymembers:lowdensitylipoproteinreceptor(LDLR),verylowdensitylipoproteinreceptor(VLDLR),apolipoproteinEreceptor(LRP1/APOER)andapolipoproteinreceptor2(LRP8/APOER2),andpromotestheirdegradation.Actsviaanon-proteolyticmechanismtoenhancethedegradationofthehepaticLDLRthroughaclathrinLDLRAP1/ARH-mediatedpathway.MaypreventtherecyclingofLDLRfromendosomestothecellsurfaceordirectittolysosomesfordegradation.CaninduceubiquitinationofLDLRleADIngtoitssubsequentdegradation.InhibitsintracellulardegradationofAPOBviatheautophagosome/lysosomepathwayinaLDLR-independentmanner.Involvedinthedisposalofnon-acetylatedintermediatesofBACE1intheearlysecretorypathway.InhibitsepithelialNa(+)channel(ENaC)-mediatedNa(+)absorptionbyreducingENaCsurfaceexpressionprimarilybyincreasingitsproteasomaldegradation.RegulatesneuronalapoptosisviamodulationofLRP8/APOER2levelsandrelatedanti-apoptoticsignalingpathways.
Description:
PCSK9NeutralizingAntibody,aneutralizingrecombinanthumanantibody(IgG1)recogniziestheLDLRbindingregionofhumanPCSK9.
Synonym(s):
Anti-PCSK9
AssayConditions:
3.8ng/µlbiotinylatedPCSK9wasincubatedwithvariousconcentrationsofAnti-PCSK9for1hrina50µlreactionmix.MixturewasincubatedonLDLRcoatedplatefor2hr.StreptavidinlabeledHRPwasaddedandincubatedfor1hr.Finally,HRPchemiluminescentsubstrateswereaddedandluminescencewasread.
Formulation:
40mMTris-HCl,pH8.0,110mMNaCl,2.2mMKCl,and20%glycerol.
Immunogen:
LDLRbindingregionofhumanPCSK9
Format:
Aqueousbuffersolution
Storage/StABIlity:
>6monthsat-80°C.
Application(s):
UsefulasaninhibitorofPCSK9-LDLRbindingusingthePCSK9[Biotinylated]-LDLRBindingAssayKit,Cat.#72002.
Reference(s):
1.Banerjee,Y.,etal.,NEnglJMed.2012Jun21,366(25):2425-6.
2.Maxwell,K.N.,Breslow,J.L.,CircRes.2012Jul20,111(3):274-7.
ApplicationReference(s):
1.Cell-based,bioluminescentassayformonitoringtheinteractionbetweenPCSK9andtheLDLreceptor(2017)
2. PCSK9isacriticalregulatoroftheinnateimmuneresponseandsepticshockoutcome(2014)
Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
Cholesterol-Related
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
