Bpsbioscience/Boc-D-FMK/27611-1/5 mg
商品编号：
27611-1
品牌：
bpsbioscience
市场价：
¥4300.00
美元价：
2580.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:263.3Da
CASRegistry#:187389-53-3,634911-80-1
Formula:C11H18FNO5
Target:pan-caspase
Background:
Boc-D-FMKisacell-permeablebroad-spectrumcaspaseinhibitorthatfullyinhibitsthepro-apoptoticeffectoftumornecrosisfactor-α(TNFα)withIC50valueof39µM.Boc-D-FMKhasbeenfoundtoreducetheactivationofnuclearfactorkappalightchainenhancerofactivatedBcells(NF-kB),suppressthephosphorylationofsubunitnuclearfactorkappalightpolypeptidegeneenhancerinBcellsinhibitorα(IkBα)andinhibitsTNF-inducedexpressionofintercellularadhesionmolecule1(ICAM-1)andvascularcelladhesionmolecule1(VCAM-1).Moreover,Boc-D-FMKhasalsoeffectivelyattenuatedthehepatocyteapoptosisinbileduct-ligatedratspotentiallyimprovingthesurvivalrates.
Synonym(s):
CaspaseInhibitorIII;Boc-Asp(OMe)-FMK;Boc-D(OMe)-FMK;Boc-Asp-Fluoromethylketone;methyl5-fluoro-3-[(2-methylpropan-2-yl)oxycarbonylamino]-4-oxopentanoate
Purity:
≥98%byHPLC
Solubility:
SolubleinDMSO
Storage/Stability:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.CowburnAS,etal.Blood.2005Apr1;105(7):2970-2.
2.WuX,etal.AmJPhysiolRenalPhysiol.2009Aug;297(2):F316-26.
3.Sheen-ChenSM,etal.JGastroenterolHepatol.2008Aug;23(8Pt1):1276-9.
2.WuX,etal.AmJPhysiolRenalPhysiol.2009Aug;297(2):F316-26.
3.Sheen-ChenSM,etal.JGastroenterolHepatol.2008Aug;23(8Pt1):1276-9.
Notes:
Theinhibitorisdesignedasamethylestertofacilitatecellpermeability.Iftheintendeduseisonpurifiedorrecombinantenzymes,esteraseshouldbeaddedtogeneratefreecarboxylgroups.
AminoAcidSequence:
Boc-Asp(OMe)-CH?F
ScientificCategory:
ApoptosisInhibitor
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
