Bpsbioscience/BIBR 1532/27740-1/25 mg
商品编号：
27740-1
品牌：
bpsbioscience
市场价：
¥4600.00
美元价：
2760.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:331.4Da
CASRegistry#:321674-73-1
Formula:C21H17NO3
Target:Telomerase
Background:
IthasbeenreportedthatBIBR1532inhibitedthereversetranscriptaseoftelomerase,hTERT,andshortenedthelengthofthetelomerasetosuppresshumancancercellproliferation.Inpre-Bacutelymphoblasticleukemiacells,BIBR1532suppressedc-MycandhTERTexpressioninaconcentration-dependentmannertoinhibittelomeraseactivity,andhighdosesofBIBR1532couldinduceapoptosisbyelevatingp73,Bax/Bcl-2andcaspase-3activation.InNB4leukemiccells,combinedtreatmentswithBIBR1532andarsenictrioxidesuppressedcellproliferativecapacityandinhibitedtelomeraseactivityprobablyviatranscriptionalsuppressionofc-MycandhTERT.
Description:
BIBR1532isanovel,specifictelomeraseinhibitorwithIC50=93nM.
Synonym(s):
2-[[(E)-3-naphthalen-2-ylbut-2-enoyl]amino]benzoicacid
Solubility:
SolubleinDMSO
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.Damm,K.,etal.EMBOJ.2001,20,6958?6968.
2.BashashD.,etal.LeukLymphoma.2013Mar;54[4]:561-8.
3.BashashD.,etal.AnticancerAgentsMedChem.2013Sep;13(7):1115-25.
2.BashashD.,etal.LeukLymphoma.2013Mar;54[4]:561-8.
3.BashashD.,etal.AnticancerAgentsMedChem.2013Sep;13(7):1115-25.
ScientificCategory:
Telomerase
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
