Bpsbioscience/盐酸苯达莫司汀/27738-1/5 mg
商品编号：
27738-1
品牌：
bpsbioscience
市场价：
¥2300.00
美元价：
1380.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:394.7Da
CASRegistry#:3543-75-7
Formula:C16H21Cl2N3O2•HCl
Background:
Bendamustineinhibitsmitoticcheckpointsandinducesmitoticcatastrophebyinhibitingseveralmitosis-relatedgenessuchasPolo-likekinase1,AurorakinaseA,andCyclinB1.Inmyelomacelllines,bendamustineinducedapoptosisbycleavageofcaspase3,andresultedinG2cellcyclearrest.Inchroniclymphocyticandmantlecelllymphomacelllines,bendamustineHClhasbeenshowntoactivateboththemitochondrialcelldeathpathwayandcaspase-dependentapoptosis.
Description:
BendamustineHClisanalkylatingagentassociatedwithDNAdamage(IC50=50µM).Itisacytostaticagentthatdisplaysactivityinnon-Hodgkin"slymphomas.
Synonym(s):
4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoicacid
BIOLOGicalActivity:
Bendamustineexhibitedanti-proliferationeffectsondexamethasone-sensitive(MM1.S)and-resistant(MM1.R)multiplemyelomacellsinadose-dependentmanner,withIC50sof119.8µM(MM1.S)and138µM(MM1.R),respectively.Theapoptosisbyactivationofcaspase-3andcaspase-8wasinducedinbothMM1.SandMM1.Rcelllines.
Solubility:
SolubleinDMSO
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
ScientificCategory:
ApoptosisInducers
ProductType:
Activator/Inducer
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
