Bpsbioscience/BCL-XL，His标签/50273/100µg
商品编号：
50273
品牌：
bpsbioscience
市场价：
¥8300.00
美元价：
4980.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Species:Human
HostSpecies:E.coli
MW:28kDa
Genbank#:Z23115
Tag(s):C-terminalHis-tag
a.a:1–212
Background:
BCL-2familymembersformhetero-orhomodimersandactasanti-orpro-apoptoticregulatorsthatareinvolvedinawidevarietyofcellularactivities.Theproteinsencodedbythisgenearelocatedattheoutermitochondrialmembrane,andhavebeenshowntoregulateoutermitochondrialmembranechannel(VDAC)opening.VDACregulatesmitochondrialmembranepotential,andthuscontrolstheproductionofreactiveoxygenspeciesandreleaseofcytochromeCbymitochondria,bothofwhicharethepotentinducersofcellapoptosis.Twoalternativelysplicedtranscriptvariants,whichencodedistinctisoforms,havebeenreported.Thelongerisoform(Bcl-xL)actsasanapoptoticinhibitorandtheshorterform(Bcl-xS)actsasanapoptoticactivator.
Description:
HumanBCL-XL(GenBankAccessionNo.Z23115),a.a.1-212withC-terminalHis-tag,MW=28kDa,expressedinanE.coliexpressionsystem.
UniProt
Q07817
Synonym(s):
Bcl-Xlong,BcelllymphomaXL,bclxl
AssayConditions:
FollowingtheprotocolforBPSCat.#50223.Briefly,BCL-XLwascombinedwithBCL-XLpeptideligandinTR-FRETassaybufferalongwithanti-HisTbdonoranddye-labeledacceptor.VaryingconcentrationsofABT199wereaddedandthereactionwasincubatedatroomtemperaturefor2hoursfollowedbyfluorescentintensitymeasurements.
Formulation:
45mMTris-HCl,pH8.0,124mMNaCl,2.4mMKCl,10%glycerol,225mMimidazoleand3mMDTT.
Format:
Aqueousbuffersolution
Application(s):
Usefulforthestudyofapoptosis,screeninginhibitors,andselectivityprofiling.
Reference(s):
1.MengY.etal.,MolCancerTher.2008Jul;7(7):2192-202.
2.AsakuraT.etal.,MolIntJOncol.2008Aug;33(2):389-95.
2.AsakuraT.etal.,MolIntJOncol.2008Aug;33(2):389-95.
Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
Apoptosis
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
