Bpsbioscience/Apoptosis Activator 2/27733-1/25 mg
商品编号：
27733-1
品牌：
bpsbioscience
市场价：
¥3900.00
美元价：
2340.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:306.1Da
CASRegistry#:79183-19-0
Formula:C15H9Cl2NO2
Target:Caspase
Background:
ApoptosisActivator2isacell-permeableindoledionecompoundthatactivatescaspasesinacytochromec-dependentmannerandinducesapoptosisintumorcellsbypromotingtheoligomerizationofApaf-1intothematureapoptosome.Itscytotoxicityisselectivetowardstumorcells(IC50<10µMforJurkat,Molt-4,andCCRF-CEM).ApoptosisActivator2showslittleornoeffectonnon-tumorcellsorcellsthataredeficientincaspase-3orApaf-1(IC50>40µM).Throughtheinductionofapoptosis,ApoptosisActivator2notablyinducescaspase-3activation,PARPcleavageandDNAfragmentation.Moreover,thisinductionofapoptosisonlyoccursintumorcelllines(suchasbreast,lung,colon,andepidermalcancercelllines).
Description:
ApoptosisActivator2isasmall,cellpermeableactivatorofcaspase-3.ApoptosisActivator2inducesapoptosisspecificallyintumorcelllines,butnotnormalcelllines,withIC50valueofabout4µM.
Synonym(s):
ApoptosisActivatorII;AG-H-17727;ZINC02276110;1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione
BIOLOGicalActivity:
Inducesapoptosisoftumorcelllines,includingBT-549:IC50=20µM;NCI-H23:IC50=35µM;Jurkat:IC50=4µM;Molt-4:IC50=6µM;andCCRF-CEM:IC50=9µM.
Solubility:
SolubleinDMSO(5mg/ml),methanol(5mg/ml),andethanol.
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.NguyenJT,WellsJA.ProcNatlAcadSciUSA.2003Jun24;100(13):7533-8.
2.NguyenTV,etal.JNeuroendocrinol.2010Sep;22(9):1013-22.
2.NguyenTV,etal.JNeuroendocrinol.2010Sep;22(9):1013-22.
ScientificCategory:
ApoptosisActivator
ProductType:
Activator/Inducer
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
