Bpsbioscience/2-甲氧基雌二醇（2-MeOE2）/27762-1/50 mg
商品编号：
27762-1
品牌：
bpsbioscience
市场价：
¥3400.00
美元价：
2040.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:302.4Da
CASRegistry#:362-07-2
Formula:C19H26O3
Background:
2-MethoxyestrADIoliscurrentlyinclinicaltrialsasatherapeuticagainstbreastandovariancancer.Preclinicalmodelsalsosuggestthat2ME2couldalsobeeffectiveagainstinflammatorydiseasessuchasrheumatoidarthritis.Severalstudieshavebeenconductedshowing2ME2isamicrotubule-inhibitorandeffectiveagainstprostatecancerinrodents
Description:
2-Methoxyestradiol(2-MeOE2),anendogenousmetaboliteof17β-estradiol(E2),isaninhibitorofmicrotubuleassemblythatinhibitsthepolymerizationoftubulinandinterfereswithmitoticspindledynamicsleadingtotheblockageofmitosisofhumancancercellswhichlackestrogenreceptorsinmetaphase.2-MeOE2isalsoaninhibitoroftumorgrowthandangiogenesis.Studyresultshaveshownthat2-MeOE2inducesmammaliancelltransformationandgenotoxicityinSyrianhamsterembryo(SHE)fibroblaststhroughconcentration-dependentinhibitionofcellgrowth.Moreover,2-MeOE2hasdemonstratedanti-proliferativeactivityagainstestrogen-responsivebreastcancercelllineMCF-7andsubsequentinhibitionofthegrowthoftumorssubcutaneouslyinoculatedinmice.
Synonym(s):
2-Methoxyestradiol;2-MeOE2;2-methoxyEstradiol
Purity:
98%puritybyHPLC
Solubility:
SolubleinDMSO~20mg/ml
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.Tsutsui,T.,etal.Carcinogensis2000;21(4):735-740.
2.Attalla,H.,etal.Biochem.Biophys.Res.Commun.1996;228:467-473.
2.Attalla,H.,etal.Biochem.Biophys.Res.Commun.1996;228:467-473.
ScientificCategory:
ApoptosisInducer
ProductType:
Activator/Inducer
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
