Bpsbioscience/C646/27613-1/10毫克
商品编号：
27613-1
品牌：
bpsbioscience
市场价：
¥3400.00
美元价：
2040.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
MW:445.4Da
CASRegistry#:328968-36-1
Formula:C24H19N3O6
Target:p300
Background:
C646bindstop300astheZ-isomerforminghydrogenbondsbetweenThr1411,tYR1467,Trp1466andArg1410onthesidechainsofp300andoxygenatomsofC646.C646isalsocapableofinhibitingavarietyofp300HATmutants,includingT1411A,Y1467F,W1466FandR1410AwithIC50valuesof3.4µM,7µM,5µMand2.5µMrespectively.
Description:
C646,apyrazolone-containingsmallmolecule,isacell-permeablehistoneacetyltransferase(HAT)inhibitorthatcompetitivelyandselectivelyinhibitstheHATactivityofp300,atranscriptionalco-activatorinvolvedinavarietyofgeneregulatorypathwaysandproteinacetylationevents,withtheKivalueof400nMandanIC50valueof1.6µM.
Synonym(s):
4-[(4Z)-4-[[5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoicacid
Solubility:
SolubleinDMSO
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
BowersEM,etal.ChemBiol.2010May28;17(5):471-82.
ScientificCategory:
HistoneAcetyltransferases
ProductType:
Inhibitor
Datashownislot-specific.Contactusforspecificinformationonotherlots.
品牌介绍
bpsbioscience简介：为生命科学研究提供ELISA试剂盒（仅供科研）、抗体和抗原（仅供科研）、流式抗体，使您的检测结果更稳定可靠，用心服务科研。我公司国内总代理,华东地区代理bpsbioscience 专业经营进口胎牛血清、细胞因子、ELISA试剂盒、细胞、抗体、生物试剂、耗材、培养基、一抗、二抗、其产品吸附均匀，吸附性好，空白值低，孔底透明度高，代做ELISA实验等。
